Effects of Sublethal Irradiation on Patterns of Engraftment after Murine Bone Marrow Transplantation

Failure Marrow Transplantation after Engraftment Promotes Engraftment for Secondary Bone Primary Bone Marrow Transplantation

MRI evaluation of rabbit bone marrow after acute irradiation

Background: Magnetic Resonance Imaging (MRI) is a safe modality and useful in characterizing normal and abnormal bone marrow (BM). MRI also presents a more global view of BM than biopsy therefore, it may provide a better understanding of hematologic disorders. The purpose of this study was to monitor radiation-induced alterations of BM in acute phase of irradiation (1-10 day after total body ir...

Determinants of engraftment after allogeneic marrow transplantation.

ESPITE RECENT improvements in posttransplant D immunosuppressive regimens, acute and chronic graftversus-host disease (GVHD) remain significant obstacles to successful marrow transplantation, particularly in patients not having an HLA-identical related donor. These findings have lead to continued interest in preventing GVHD by depleting T cells from the donor marrow. Initial animal experiments ...

Evaluation of the Repair of Bone Defect after Bone Marrow Stromal Cell Transplantation in Rat

Background & Objective: Bone marrow stromal cells (BMSCs) are multipotent stem cells that can proliferate and differentiate into osteogenic cells . T his study aimed to investigate the effects of BMSC transplantation for the repair of bone defects in the rat.   Materials & Methods : Twenty-eight male adult rats were divided into 4 groups. Group 1 ( control group) received no treatment after the...

Extrathymic development of murine T cells after bone marrow transplantation.

Restoring T cell competence is a significant clinical challenge in patients whose thymic function is severely compromised due to age or cytoreductive conditioning. Here, we demonstrate in mice that mesenteric LNs (MLNs) support extrathymic T cell development in euthymic and athymic recipients of bone marrow transplantation (BMT). Furthermore, in aged murine BMT recipients, the contribution of t...